NH(3)-dependent NAD(+) synthetase

BE0001332ProteinEscherichia coli (strain K12)nadE

Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. It is acted on by 2 drugs in DrugBank.

Gene name
nadE
UniProtKB entry
P18843Swiss-Prot
Residues / weight
275 residues · 30,637 Da
Also known as
6.3.1.5 · efg · NADS · Nicotinamide adenine dinucleotide synthetase · Nitrogen regulatory protein

Resolves to

Protein
UniProtP18843UniProt nameNADE_ECOLI
Gene
NCBI Gene946946GenBank146974
Pharmacology
KEGGecj:JW1729
Structure
PDB1WXEPDB1WXFPDB1WXG
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NH(3)-dependent NAD(+) synthetase, and which indications are they being tested in?

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