UDP-3-O-acyl-N-acetylglucosamine deacetylase

BE0001333ProteinAquifex aeolicus (strain VF5)lpxC

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. It is acted on by 5 drugs in DrugBank.

Gene name
lpxC
UniProtKB entry
O67648Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
282 residues · 32,145 Da
Also known as
3.5.1.- · 3.5.1.108 · envA · UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase · UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase

Resolves to

Protein
UniProtO67648UniProt nameLPXC_AQUAE
Gene
NCBI Gene1193363GenBank2984065
Pharmacology
KEGGaae:aq_1772
Structure
PDB1P42PDB1XXEPDB1YH8
Drugs

What you can answer from here — as of May 03, 2025

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on UDP-3-O-acyl-N-acetylglucosamine deacetylase, and which indications are they being tested in?

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