Gag-Pol polyprotein
Details
- Name
- Gag-Pol polyprotein
- Kind
- protein
- Synonyms
- Pr160Gag-Pol
- Gene Name
- gag-pol
- UniProtKB Entry
- P12499Swiss-Prot
- Organism
- HIV-1
- NCBI Taxonomy ID
- 11683
- Amino acid sequence
>lcl|BSEQ0002665|Gag-Pol polyprotein MGARASVLSGGKLDAWEKIRLRPGGKKKYRLKHLVWASRELERFALNPGLLETSDGCKQI IGQLQPAIRTGSEELRSLFNTVATLYCVHERIEVKDTKEALEKMEEEQNKSKNKKAQQAA ADAGNNSQVSQNYPIVQNLQGQMVHQAISPRTLNAWVKVIEEKAFSPEVIPMFSALSEGA TPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGT TSTLQEQIAWMTSNPPIPVGEIYKRWIILGLNKIVRMYSPVSILDIRQGPKEPFRDYVDR FYKTLRAEQASQEVKGWMTETLLVQNANPDCKTILKALGPQATLEEMMTACQGVGGPSHK ARVLAEAMSQATNSAAAVMMQRGNFKGPRKTIKCFNCGKEGHIAKNCRAPRRKGCWKCGK EGHQLKDCTERQANFLREDLAFPQGKAGELSSEQTRANSPTSRELRVWGRDNPLSETGAE RQGTVSFNCPQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIG GFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKL KPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRVGPENPYNTPIFAIKKKDSTKWR KLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTI PSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVIYQYMDDLYVGSD LEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQSIKLPEKESW TVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKE PVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLAEVV QKISTESIVIWGKTPKFRLPIQKETWETWWVEYWQATWIPEWEFVNTPPLVKLWYQLEKE PIIGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPFTDTTNQKTELQAINLALQDSGLE VNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV SQGIRKVLFLDGIDKAQEEHEKYHNNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHG QVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKI VHTDNGSNFTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHL KTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRD PIWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
- Number of residues
- 1436
- Molecular Weight
- 161898.155
- Theoretical pI
- 9.03
- GO Classification
- Functionsaspartic-type endopeptidase activity / DNA binding / DNA-directed DNA polymerase activity / exoribonuclease H activity / lipid binding / RNA binding / RNA-directed DNA polymerase activity / RNA-DNA hybrid ribonuclease activity / structural molecule activity / zinc ion bindingProcessesDNA integration / DNA recombination / establishment of integrated proviral latency / induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process / suppression by virus of host gene expression / viral entry into host cell / viral penetration into host nucleus / viral release from host cellComponentshost cell nucleus / host cell plasma membrane / host multivesicular body / viral nucleocapsid / virion membrane
- General Function
- Gag-Pol polyprotein Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shut off translation.
- Specific Function
- aspartic-type endopeptidase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Host cell membrane
- Gene sequence
>lcl|BSEQ0002664|3009 bp TTTTTTAGGGAAGATTTGGCCTTCCCACAAGGGAAGGCCGGGGAACTTTCTTCAGAGCAG ACCAGAGCCAACAGCCCCACCAGCAGAGAGCTTCGGGTTTGGGGAAGAGATAACCCCCTC TCAGAAACAGGAGCAGAAAGACAAGGAACTGTATCCTTCAACTGCCCTCAAATCACTCTT TGGCAACGACCCCTTGTTACAATAAAAATAGGGGGACAGCTAAAGGAAGCTCTATTAGAT ACAGGAGCAGATGATACAGTATTAGAAGAAATGAATTTGCCAGGAAAATGGAAACCAAAA ATGATAGGGGGAATTGGAGGTTTTATCAAAGTAAGACAGTATGATCAAATACTCATAGAA ATCTGTGGGCATAAAGCTATAGGTACAGTATTAGTAGGACCTACACCTGTCAACATAATT GGAAGAAATTTGTTGACCCAGATTGGCTGCACTTTAAATTTTCCAATTAGTCCTATTGAA ACTGTACCAGTAAAATTAAAGCCAGGAATGGATGGCCCAAAAGTTAAACAATGGCCATTG ACAGAAGAAAAAATAAAAGCATTAACAGAAATTTGTACAGAAATGGAAAAGGAAGGAAAA ATTTCAAGAGTTGGGCCTGAAAATCCATACAATACTCCCATATTTGCCATAAAGAAAAAA GACAGTACCAAGTGGAGAAAATTAGTAGATTTCAGGGAACTTAATAAGAGAACTCAAGAT TTCTGGGAAGTTCAATTAGGAATACCGCATCCGGCAGGGCTAAAAAAGAAAAAATCAGTA ACAGTACTGGATGTGGGTGATGCATATTTTTCAGTTCCCTTAGATAAAGACTTTAGGAAA TATACTGCATTTACCATACCTAGTATAAATAATGAGACACCAGGGATTAGATATCAGTAC AATGTGCTTCCACAGGGATGGAAAGGATCACCGGCAATATTCCAAAGTAGCATGACAAAA ATCTTAGAGCCCTTTAGAAAACAAAATCCAGAAATAGTTATCTATCAATACATGGATGAT TTGTATGTAGGATCTGACTTAGAAATAGGGCAGCATAGAACAAAAATAGAGGAATTAAGA GAACATCTATTAAGGTGGGGATTTACCACACCAGATAAAAAACATCAGAAAGAACCCCCA TTTCTTTGGATGGGGTATGAACTCCATCCTGATAAATGGACAGTACAGTCTATAAAATTG CCAGAAAAGGAGAGCTGGACTGTCAATGATATACAGAAGTTAGTGGGGAAATTAAACTGG GCAAGCCAGATTTATCCAGGAATTAAAGTAAGGCAATTGTGTAAACTCCTTAGGGGAACC AAAGCACTAACAGAAGTAATACCACTAACAGAAGAAGCAGAATTAGAACTGGCAGAAAAC AGGGAAATTCTAAAAGAACCAGTACATGGAGTGTATTATGACCCATCAAAAGACTTAATA GCAGAAATACAGAAACAAGGGCACGGCCAATGGACATACCAAATTTATCAAGAACCATTT AAAAATCTGAAAACAGGAAAGTATGCAAGAATGAGGGGTGCCCACACTAATGATGTAAAA CAATTAGCAGAGGTAGTGCAAAAAATATCCACAGAAAGCATAGTGATATGGGGAAAGACT CCTAAATTTAGATTACCCATACAAAAGGAAACATGGGAAACATGGTGGGTAGAGTATTGG CAAGCCACTTGGATTCCTGAGTGGGAATTTGTCAATACCCCTCCTTTAGTAAAATTATGG TACCAGTTAGAGAAGGAACCCATAATAGGAGCAGAAACTTTCTATGTAGATGGGGCAGCT AATAGAGAGACTAAATTAGGAAAGGCAGGATATGTTACTGACAGAGGAAGACAGAAAGTT GTCCCTTTTACTGATACAACAAATCAGAAGACTGAGTTACAAGCAATTAATTTAGCTTTG CAGGATTCGGGATTAGAAGTAAACATAGTAACAGATTCACAATATGCATTAGGAATCATT CAAGCACAACCAGATAAGAGTGAATCAGAGTTAGTCAGTCAAATAATAGAGCAGTTAATA AAAAAGGAAAAGGTTTACCTGGCATGGGTACCAGCACATAAAGGAATTGGAGGAAATGAA CAAGTAGATAAATTAGTCAGTCAGGGAATCAGGAAAGTACTATTTTTGGATGGAATAGAT AAAGCTCAAGAAGAACATGAGAAATATCACAACAATTGGAGAGCAATGGCTAGTGATTTT AACCTACCACCTGTGGTAGCAAAAGAAATAGTAGCTAGCTGTGATAAATGTCAGCTAAAA GGAGAAGCCATGCATGGACAAGTAGACTGTAGTCCAGGAATATGGCAATTAGATTGTACA CATTTAGAAGGAAAAGTTATCCTGGTAGCAGTTCATGTAGCCAGTGGCTATATAGAAGCA GAAGTTATTCCAGCAGAAACAGGGCAGGAAACAGCATATTTTATTTTAAAATTAGCAGGA AGATGGCCAGTAAAAATAGTACATACAGACAATGGCAGCAATTTCACCAGTGCTGCAGTT AAGGCTGCCTGTTGGTGGGCAGGTATTAAACAGGAATTTGGAATTCCCTACAATCCCCAA AGTCAAGGAGTAGTAGAATCTATGAATAAAGAATTGAAGAAAATTATAGGACAGGTAAGA GATCAAGCTGAGCATCTTAAGACAGCTGTACAAATGGCAGTATTCATCCACAATTTTAAA AGAAAAGGGGGGATTGGGGGATACAGTGCAGGGGAGAGAATAATAGACATAATAGCAACA GACATACAAACTAAAGAATTACAAAAACAAATCACAAAAATTCAAAATTTTCGGGTTTAT TACAGGGACAGCAGAGATCCAATTTGGAAAGGACCAGCAAAGCTCCTCTGGAAAGGTGAA GGGGCAGTAGTAATACAAGACAATAGTGACATAAAGGTAGTACCAAGAAGAAAAGTAAAG ATTATCAGGGATTATGGAAAACAGATGGCAGGTGATGATTGTGTGGCAAGTAGACAGGAT GAGGATTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P12499 UniProtKB Entry Name POL_HV1Z2 GenBank Protein ID 329380 GenBank Gene ID M22639 PDB ID(s) 1E28, 1HXW, 1P7Q, 1PRO, 1Q94, 1VIJ, 1VIK, 2WKZ, 2WL0, 2XYE, 2XYF, 3KF0, 3KFN, 3KFP, 3KFR, 3KFS, 3W39, 4DQB, 4DQC, 4DQE, 4DQF, 4DQG, 4DQH, 4E43, 4EJ8, 4EJD, 4EJK, 4EJL, 4K4P, 4K4Q, 4K4R - General References
- Vogt VM: Proteolytic processing and particle maturation. Curr Top Microbiol Immunol. 1996;214:95-131. [Article]
- Turner BG, Summers MF: Structural biology of HIV. J Mol Biol. 1999 Jan 8;285(1):1-32. [Article]
- Negroni M, Buc H: Mechanisms of retroviral recombination. Annu Rev Genet. 2001;35:275-302. [Article]
- Dunn BM, Goodenow MM, Gustchina A, Wlodawer A: Retroviral proteases. Genome Biol. 2002;3(4):REVIEWS3006. Epub 2002 Mar 26. [Article]
- Scarlata S, Carter C: Role of HIV-1 Gag domains in viral assembly. Biochim Biophys Acta. 2003 Jul 11;1614(1):62-72. [Article]
- Kempf DJ, Marsh KC, Denissen JF, McDonald E, Vasavanonda S, Flentge CA, Green BE, Fino L, Park CH, Kong XP, et al.: ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2484-8. [Article]
- Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W Jr, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW: A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease. J Med Chem. 1996 Jan 19;39(2):392-7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N,N-[2,5-O-Dibenzyl-glucaryl]-DI-[1-amino-indan-2-OL] experimental unknown target Details A-98881 experimental unknown target Details Tert-butyl N-[(2S,5R)-6-[[(2S)-5-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-benzyl-3,6-dioxo-1-phenylhexan-2-yl]carbamate experimental unknown target Details