Tryptophan--tRNA ligase

BE0001343ProteinGeobacillus stearothermophilustrpS

Catalyzes the attachment of tryptophan to tRNA(Trp). It is acted on by 3 drugs in DrugBank.

Gene name
trpS
UniProtKB entry
P00953Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
328 residues · 37,192 Da
Also known as
6.1.1.2 · TrpRS · Tryptophanyl-tRNA synthetase

Resolves to

Protein
UniProtP00953UniProt nameSYW_GEOSE
Gene
GenBank143784
Structure
PDB1D2RPDB1I6KPDB1I6L
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptophan--tRNA ligase, how selective are they, and which programs against it are still in active trials?

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