ADP-ribose pyrophosphatase
Details
- Name
- ADP-ribose pyrophosphatase
- Kind
- protein
- Synonyms
- 3.6.1.13
- Adenosine diphosphoribose pyrophosphatase
- ADP-ribose diphosphatase
- ADP-ribose phosphohydrolase
- ADPR-PPase
- aspP
- ASPPase
- Gene Name
- nudF
- UniProtKB Entry
- P83844Swiss-Prot
- Organism
- Shigella flexneri
- NCBI Taxonomy ID
- 623
- Amino acid sequence
>lcl|BSEQ0010940|ADP-ribose pyrophosphatase MLKPDNLPVTFGKNDVEIIARETLYRGFFSLDLYRFRHRLFNGQMSHEVRREIFERGHAA VLLPFDPVRDEVVLIEQIRIAAYDTSETPWLLEMVAGMIEEGESVEDVARREAIEEAGLI VKRTKPVLSFLASPGGTSERSSIMVGEVDATTASGIHGLADENEDIRVHVVSREQAYQWV EEGKIDNAASVIALQWLQLHHQALKNEWA
- Number of residues
- 209
- Molecular Weight
- 23666.61
- Theoretical pI
- 4.72
- GO Classification
- FunctionsADP-ribose diphosphatase activity / metal ion binding
- General Function
- Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity).
- Specific Function
- ADP-ribose diphosphatase activity
- Pfam Domain Function
- Not Available
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0010941|ADP-ribose pyrophosphatase (nudF) ATGCTTAAGCCAGACAACCTGCCCGTTACATTTGGCAAAAACGATGTAGAAATTATTGCA CGAGAAACACTTTATCGCGGCTTTTTTTCATTAGATCTTTATAGATTTCGTCATCGTCTA TTCAACGGGCAAATGAGTCATGAGGTACGGCGGGAAATTTTTGAGCGCGGTCACGCCGCA GTCTTGCTACCCTTTGACCCAGTGCGTGATGAAGTTGTGCTGATTGAGCAGATTCGGATT GCCGCGTACGACACCAGCGAAACCCCCTGGCTACTGGAGATGGTTGCCGGGATGATTGAA GAGGGTGAAAGTGTGGAAGATGTTGCCCGTCGCGAAGCGATTGAAGAGGCGGGACTGATA GTCAAACGGACCAAACCGGTGTTAAGTTTCCTGGCAAGCCCGGGGGGCACCAGTGAGCGT TCGTCAATTATGGTGGGCGAAGTGGACGCCACGACCGCAAGCGGTATTCATGGTCTGGCT GATGAAAACGAAGATATTCGCGTTCATGTGGTAAGCCGGGAACAGGCATACCAGTGGGTA GAAGAGGGGAAAATCGACAACGCAGCGTCGGTCATCGCTTTGCAATGGCTGCAGCTGCAT CATCAAGCGTTAAAAAATGAGTGGGCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P83844 UniProtKB Entry Name ADPP_SHIFL GenBank Protein ID 24053496 GenBank Gene ID AE005674 KEGG ID sfl:SF3074 NCBI Gene ID 1026699 - General References
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
- Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details AMPCPR experimental unknown target Details Adenosine-5-Diphosphoribose experimental unknown target Details