pH-gated potassium channel KcsA

BE0001355ProteinStreptomyces lividanskcsA

Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. It is acted on by 3 drugs in DrugBank.

Gene name
kcsA
UniProtKB entry
P0A334Swiss-Prot
Cellular location
Cell membrane
Residues / weight
160 residues · 17,693 Da
Also known as
skc1 · Streptomyces lividans K+ channel

Resolves to

Protein
UniProtP0A334UniProt nameKCSA_STRLI
Gene
GenBank1089906
Structure
PDB1BL8PDB1F6GPDB1J95
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on pH-gated potassium channel KcsA, and which indications are they being tested in?

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