Deoxyuridine 5'-triphosphate nucleotidohydrolase

BE0001364ProteinEscherichia coli (strain K12)dut

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. It is acted on by 4 drugs in DrugBank.

Gene name
dut
UniProtKB entry
P06968Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
151 residues · 16,155 Da
Also known as
3.6.1.23 · dnaS · dUTP pyrophosphatase · dUTPase · sof

Resolves to

Protein
UniProtP06968UniProt nameDUT_ECOLI
Gene
NCBI Gene948607GenBank41297
Pharmacology
KEGGecj:JW3615
Structure
PDB1DUDPDB1DUPPDB1EU5
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Deoxyuridine 5'-triphosphate nucleotidohydrolase, and which indications are they being tested in?

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