Diphtheria toxin

BE0001370ProteinCorynephage omega

Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2. It is acted on by 1 drug in DrugBank.

UniProtKB entry
P00587Swiss-Prot
Residues / weight
560 residues · 60,814 Da
Also known as
DT · NAD(+)--diphthamide ADP-ribosyltransferase

Resolves to

Protein
UniProtP00587UniProt nameDTX_COROM
Gene
GenBank579179
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Diphtheria toxin, and which indications are they being tested in?

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