3-phosphoshikimate 1-carboxyvinyltransferase

BE0001381ProteinEscherichia coli (strain K12)aroA

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. It is acted on by 4 drugs in DrugBank.

Gene name
aroA
UniProtKB entry
P0A6D3Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
427 residues · 46,095 Da
Also known as
2.5.1.19 · 5-enolpyruvylshikimate-3-phosphate synthase · EPSP synthase · EPSPS

Resolves to

Protein
UniProtP0A6D3UniProt nameAROA_ECOLI
Gene
NCBI Gene945528GenBank40966
Pharmacology
KEGGecj:JW0891
Structure
PDB1EPSPDB1G6SPDB1G6T
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-phosphoshikimate 1-carboxyvinyltransferase, how selective are they, and which programs against it are still in active trials?

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