Pantothenate synthetase

BE0001387ProteinMycobacterium tuberculosispanC

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. It is acted on by 4 drugs in DrugBank.

Gene name
panC
UniProtKB entry
P9WIL5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
309 residues · 32,677 Da
Also known as
6.3.2.1 · Pantoate--beta-alanine ligase · Pantoate-activating enzyme · PS

Resolves to

Protein
UniProtP9WIL5UniProt namePANC_MYCTU
Gene
NCBI Gene885459
Pharmacology
KEGGmtu:Rv3602c
Structure
PDB1MOPPDB1N2BPDB1N2E
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Pantothenate synthetase, and which indications are they being tested in?

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