Pol polyprotein

BE0001400ProteinFIVpol

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. It is acted on by 6 drugs in DrugBank.

Gene name
pol
UniProtKB entry
P16088Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
1,124 residues · 127,493 Da
Also known as
2.7.7.49 · RT

Resolves to

Protein
UniProtP16088UniProt namePOL_FIVPE
Gene
GenBank323935
Structure
PDB1B11PDB1DUTPDB1F7D
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Pol polyprotein, and which indications are they being tested in?

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