Tyrosine-protein kinase transforming protein Src
Details
- Name
- Tyrosine-protein kinase transforming protein Src
- Kind
- protein
- Synonyms
- 2.7.10.2
- p60-Src
- pp60v-src
- v-Src
- Gene Name
- V-SRC
- UniProtKB Entry
- P63185Swiss-Prot
- Organism
- RSV-SR-E
- NCBI Taxonomy ID
- 270623
- Amino acid sequence
>lcl|BSEQ0010983|Tyrosine-protein kinase transforming protein Src MGSSKSKPKGPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKL FGDFNTSDTVTSPQRAGALAGGVTTFVALYDYESWIETDLSFKKGERLQIVNNTEGNWWL AHSVTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETT KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHR LTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG TMSPEAFLQEAQVMKKLRHKKLVQLYAVVSEEPIYIVIEYMSKGSLLDFLKGEMGKYLRL PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYR MPCPPECPESLHDLMSQCWRRDPEERPTFEYLQAQLLPACVLEVAE
- Number of residues
- 526
- Molecular Weight
- 58952.655
- Theoretical pI
- 8.43
- GO Classification
- FunctionsATP binding / non-membrane spanning protein tyrosine kinase activity
- General Function
- This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.
- Specific Function
- ATP binding
- Pfam Domain Function
- SH3_1 (PF00018)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002780|1581 bp ATGGGGAGTAGCAAGAGCAAGCCTAAGGGCCCCAGCCAGCGCCGGCGCAGCCTGGAGCCA CCCGACAGCACCCACCACGGGGGATTCCCAGCCTCGCAGACCCCCAACAAGACAGCAGCC CCCGACACGCACCGGACCCCCAGCCGCTCCTTCGGGACCGTGGCCACCGAGCCCAAGCTC TTCGGGGACTTCAACACTTCTGACACCGTTACGTCGCCGCAGCGTGCCGGGGCACTGGCT GGCGGCGTCACCACTTTCGTGGCTCTCTACGACTACGAGTCCTGGATTGAAACGGACTTG TCCTTCAAGAAAGGAGAACGCCTGCAGATTGTCAACAACACGGAAGGTAACTGGTGGCTG GCTCATTCCGTGACTACAGGACAGACGGGCTACATCCCCAGTAACTATGTCGCGCCCTCA GACTCCATCCAGGCTGAAGAGTGGTACTTTGGGAAGATCACTCGTCGGGAGTCCGAGCGG CTGCTGCTCAACCCCGAAAACCCCCGGGGAACCTTCTTGGTCCGGGAGAGCGAGACGACA AAAGGTGCCTATTGCCTCTCCGTTTCTGACTTTGACAACGCCAAGGGGCTCAATGTGAAG CACTACAAGATCCGCAAGCTGGACAGCGGCGGCTTCTACATCACCTCACGCACACAGTTC AGCAGCCTGCAGCAGCTGGTGGCCTACTACTCCAAACATGCTGATGGCTTGTGCCACCGC CTGACCAACGTCTGCCCCACGTCCAAGCCCCAGACCCAGGGACTCGCCAAAGACGCGTGG GAAATCCCCCGGGAGTCGCTGCGGCTGGAGGTGAAGCTGGGGCAGGGCTGCTTTGGAGAG GTCTGGATGGGGACCTGGAACGGCACCACCAGAGTGGCCATAAAGACTCTGAAGCCCGGC ACCATGTCCCCGGAGGCCTTCCTGCAGGAAGCCCAAGTGATGAAGAAGCTCCGGCATAAG AAGCTGGTTCAACTGTACGCAGTGGTGTCGGAAGAGCCCATCTACATCGTCATTGAGTAC ATGAGCAAGGGGAGCCTCCTGGATTTCCTGAAGGGAGAGATGGGCAAGTACCTGCGGCTG CCACAGCTCGTTGATATGGCTGCTCAGATTGCATCCGGCATGGCCTATGTGGAGAGGATG AACTACGTGCACCGAGACCTGCGGGCGGCCAACATCCTGGTGGGGGAGAACCTGGTGTGC AAGGTGGCTGACTTTGGGCTGGCACGCCTCATCGAGGACAACGAGTACACAGCACGGCAA GGTGCCAAGTTCCCCATCAAGTGGACAGCCCCCGAGGCAGCCCTCTATGGCCGGTTCACC ATCAAGTCGGATGTCTGGTCCTTCGGCATCCTGCTGACTGAGCTGACCACCAAGGGCCGG GTGCCATACCCAGGGATGGGCAACGGGGAGGTGCTGGACCGGGTGGAGAGGGGCTACCGC ATGCCCTGCCCGCCCGAGTGCCCCGAGTCGCTGCATGACCTTATGAGCCAGTGTTGGCGG AGGGACCCTGAGGAGCGGCCCACTTTTGAGTACCTGCAGGCCCAGCTGCTCCCTGCTTGT GTGTTGGAGGTCGCTGAGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P63185 UniProtKB Entry Name SRC_RSVSE GenBank Protein ID 61909 GenBank Gene ID X13745 PDB ID(s) 2JYQ - General References
- Barnier JV, Dezelee P, Marx M, Calothy G: Nucleotide sequence of the src gene of the Schmidt-Ruppin strain of Rous sarcoma virus type E. Nucleic Acids Res. 1989 Feb 11;17(3):1252. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 4-[3-carboxymethyl-3-(4-phosphonooxy-benzyl)-ureido]-4-[(3-cyclohexyl-propyl)-methyl-carbamoyl]butyric acid experimental unknown target Details