Queuine tRNA-ribosyltransferase

BE0001405ProteinZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)tgt

Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). It is acted on by 23 drugs in DrugBank.

Gene name
tgt
UniProtKB entry
P28720Swiss-Prot
Residues / weight
386 residues · 42,842 Da
Also known as
2.4.2.29 · Guanine insertion enzyme · tRNA-guanine transglycosylase

Resolves to

Protein
UniProtP28720UniProt nameTGT_ZYMMO
Gene
GenBank498141
Pharmacology
KEGGzmo:ZMO0363
Structure
PDB1EFZPDB1ENUPDB1F3E
Drugs

What you can answer from here — as of September 07, 2019

23DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Queuine tRNA-ribosyltransferase, and which indications are they being tested in?

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