Cocaine esterase

BE0001413ProteinRhodococcus sp. (strain MB1 Bresler)cocE

Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of... It is acted on by 4 drugs in DrugBank.

Gene name
cocE
UniProtKB entry
Q9L9D7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
574 residues · 62,131 Da
Also known as
3.1.1.84

Resolves to

Protein
UniProtQ9L9D7UniProt nameCOCE_RHOSM
Gene
GenBank7229394
Structure
PDB1JU3PDB1JU4PDB1L7Q
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cocaine esterase, how selective are they, and which programs against it are still in active trials?

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