Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

BE0001414ProteinHumansMAN1B1

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It is acted on by 4 drugs in DrugBank.

Gene name
MAN1B1
UniProtKB entry
Q9UKM7Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
699 residues · 79,579 Da
Also known as
3.2.1.113 · ER alpha-1,2-mannosidase · ER mannosidase 1 · ERMan1 · Man9GlcNAc2-specific-processing alpha-mannosidase

Resolves to

Protein
UniProtQ9UKM7UniProt nameMA1B1_HUMAN
Gene
HGNCHGNC:6823NCBI Gene11253GenBank6066222GeneCardsMAN1B1
Pharmacology
KEGGhsa:11253
Structure
PDB1FMIPDB1FO2PDB1FO3
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, and which indications are they being tested in?

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