UDP-N-acetylglucosamine 2-epimerase

BE0001428ProteinEscherichia coli (strain K12)wecB

Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. It is acted on by 2 drugs in DrugBank.

Gene name
wecB
UniProtKB entry
P27828Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
376 residues · 42,244 Da
Also known as
5.1.3.14 · Bacteriophage N4 adsorption protein C · nfrC · rffE · UDP-GlcNAc-2-epimerase

Resolves to

Protein
UniProtP27828UniProt nameWECB_ECOLI
Gene
NCBI Gene944789GenBank148189
Pharmacology
KEGGecj:JW5600
Structure
PDB1F6DPDB1VGV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on UDP-N-acetylglucosamine 2-epimerase, and which indications are they being tested in?

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