Shikimate dehydrogenase (NADP(+))

Details

Name
Shikimate dehydrogenase (NADP(+))
Kind
protein
Synonyms
  • 1.1.1.25
  • SDH
Gene Name
aroE
UniProtKB Entry
P43876Swiss-Prot
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
NCBI Taxonomy ID
71421
Amino acid sequence
>lcl|BSEQ0016436|Shikimate dehydrogenase (NADP(+))
MDLYAVWGNPIAQSKSPLIQNKLAAQTHQTMEYIAKLGDLDAFEQQLLAFFEEGAKGCNI
TSPFKERAYQLADEYSQRAKLAEACNTLKKLDDGKLYADNTDGIGLVTDLQRLNWLRPNQ
HVLILGAGGATKGVLLPLLQAQQNIVLANRTFSKTKELAERFQPYGNIQAVSMDSIPLQT
YDLVINATSAGLSGGTASVDAEILKLGSAFYDMQYAKGTDTPFIALCKSLGLTNVSDGFG
MLVAQAAHSFHLWRGVMPDFVSVYEQLKKAML
Number of residues
272
Molecular Weight
29759.815
Theoretical pI
6.12
GO Classification
Functions
NADP binding / shikimate 3-dehydrogenase (NADP+) activity
Processes
aromatic amino acid family biosynthetic process / chorismate biosynthetic process / shikimate metabolic process
General Function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Specific Function
NADP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016437|Shikimate dehydrogenase (NADP(+)) (aroE)
ATGGATCTTTATGCTGTGTGGGGCAATCCGATTGCGCAAAGTAAATCGCCGTTAATTCAA
AATAAGTTAGCCGCACAAACCCATCAAACTATGGAATACATTGCAAAATTAGGCGATCTT
GATGCTTTTGAACAACAGCTTTTGGCATTTTTTGAGGAGGGTGCGAAAGGTTGCAATATT
ACTTCGCCTTTTAAAGAACGCGCTTATCAGCTGGCAGACGAATATAGCCAACGAGCAAAA
CTGGCGGAAGCCTGTAATACGCTAAAAAAACTCGATGATGGAAAACTTTATGCGGATAAC
ACTGATGGGATTGGCTTAGTGACGGATTTACAACGTTTAAATTGGCTTCGTCCAAATCAG
CACGTATTAATCTTGGGGGCGGGCGGAGCAACAAAAGGCGTATTATTGCCACTTTTACAA
GCTCAACAAAACATTGTGCTTGCTAACCGCACTTTTTCGAAAACCAAAGAATTAGCTGAA
AGATTTCAGCCTTACGGCAATATTCAAGCTGTCTCTATGGATTCGATTCCGCTACAAACT
TATGATTTGGTGATTAATGCAACTTCCGCTGGATTAAGTGGTGGAACGGCTTCAGTTGAT
GCTGAAATTTTAAAATTGGGCTCGGCTTTTTATGATATGCAATATGCGAAAGGCACAGAC
ACGCCATTTATTGCATTATGCAAAAGTTTAGGTTTAACCAATGTTAGCGATGGCTTTGGA
ATGTTAGTCGCACAAGCAGCACATTCTTTCCATTTATGGCGAGGCGTAATGCCAGATTTT
GTCTCGGTTTATGAACAGCTTAAAAAGGCGATGTTATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP43876
UniProtKB Entry NameAROE_HAEIN
GenBank Protein ID1573653
GenBank Gene IDL42023
PDB ID(s)1P74, 1P77
KEGG IDhin:HI0655
NCBI Gene ID949697
General References
  1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
  2. Ye S, Von Delft F, Brooun A, Knuth MW, Swanson RV, McRee DE: The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode. J Bacteriol. 2003 Jul;185(14):4144-51. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2'-Monophosphoadenosine-5'-DiphosphateexperimentalunknowntargetDetails