2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

BE0001450ProteinEscherichia coli (strain K12)folK

Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. It is acted on by 7 drugs in DrugBank.

Gene name
folK
UniProtKB entry
P26281Swiss-Prot
Residues / weight
159 residues · 18,079 Da
Also known as
2.7.6.3 · 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase · 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase · HPPK · PPPK

Resolves to

Protein
UniProtP26281UniProt nameHPPK_ECOLI
Gene
NCBI Gene948792GenBank146013
Pharmacology
KEGGecj:JW0138
Structure
PDB1DY3PDB1EQ0PDB1EQM
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, and which indications are they being tested in?

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