Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Details

Name
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Kind
protein
Synonyms
  • 2.7.1.49
  • HMP kinase
  • HMP-P kinase
  • HMP-phosphate kinase
  • HMPP kinase
  • Hydroxymethylpyrimidine kinase
  • Hydroxymethylpyrimidine phosphate kinase
Gene Name
thiD
UniProtKB Entry
P55882Swiss-Prot
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
NCBI Taxonomy ID
99287
Amino acid sequence
>lcl|BSEQ0019118|Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
MQRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTCGVQSVYRIEPDFV
AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRHHVRNVVLDTVMLAKSGDPLLSPS
AIETLRVRLLPQVSLITPNLPEAAALLDAPHARTEQEMLAQGRALLAMGCEAVLMKGGHL
EDAQSPDWLFTREGEQRFSAPRVNTKNTHGTGCTLSAALAALRPRHRSWGETVNEAKAWL
SAALAQADTLEVGKGIGPVHHFHAWW
Number of residues
266
Molecular Weight
28543.305
Theoretical pI
6.42
GO Classification
Functions
ATP binding / hydroxymethylpyrimidine kinase activity / phosphomethylpyrimidine kinase activity
Processes
thiamine biosynthetic process / thiamine diphosphate biosynthetic process
General Function
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0019119|Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (thiD)
ATGCAACGAATTAACGCGCTGACGATTGCCGGCACCGATCCCAGCGGCGGGGCCGGTATC
CAGGCGGATCTCAAGACCTTTTCCGCGCTGGGCGCATATGGCTGTTCGGTCATCACTGCG
CTGGTGGCGCAAAATACCTGTGGCGTACAGTCGGTGTACCGGATAGAGCCGGACTTTGTT
GCCGCTCAACTTGATTCCGTGTTCAGCGATGTGCGCATTGATACCACGAAAATCGGGATG
CTGGCGGAAACCGATATTGTCGAGGCCGTGGCGGAACGGTTACAGCGCCATCATGTACGT
AATGTGGTGCTGGATACGGTGATGCTGGCGAAAAGCGGCGATCCGCTGCTCTCGCCCTCT
GCGATAGAAACATTACGCGTCCGGCTGTTGCCGCAGGTATCGCTGATTACGCCTAATTTG
CCGGAAGCCGCAGCGTTGCTGGATGCGCCCCATGCGCGTACGGAACAGGAGATGCTGGCG
CAGGGGCGGGCGTTACTGGCGATGGGGTGTGAAGCGGTATTGATGAAAGGCGGGCATTTA
GAGGATGCGCAAAGCCCGGACTGGCTCTTTACCCGCGAGGGCGAGCAGCGTTTTAGCGCG
CCGCGTGTGAACACCAAAAATACGCATGGGACGGGCTGTACGCTGTCGGCGGCGCTGGCG
GCGTTACGGCCCCGGCATCGCAGTTGGGGAGAGACGGTAAACGAGGCGAAGGCATGGCTT
TCGGCGGCGCTGGCGCAGGCGGACACGCTGGAAGTGGGGAAGGGCATTGGTCCGGTACAT
CATTTCCACGCGTGGTGGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP55882
UniProtKB Entry NameTHID_SALTY
GenBank Protein ID1842117
GenBank Gene IDU87940
PDB ID(s)1JXH, 1JXI, 1LLJ
KEGG IDstm:STM2146
NCBI Gene ID1253667
General References
  1. Petersen LA, Downs DM: Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis. J Bacteriol. 1997 Aug;179(15):4894-900. [Article]
  2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
  3. Cheng G, Bennett EM, Begley TP, Ealick SE: Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Structure. 2002 Feb;10(2):225-35. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
4-Amino-5-Hydroxymethyl-2-MethylpyrimidineexperimentalunknowntargetDetails