4-hydroxy-tetrahydrodipicolinate synthase

BE0001460ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)dapA

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). It is acted on by 1 drug in DrugBank.

Gene name
dapA
UniProtKB entry
Q9X1K9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
294 residues · 32,390 Da
Also known as
4.3.3.7 · HTPA synthase

Resolves to

Protein
UniProtQ9X1K9UniProt nameDAPA_THEMA
Gene
NCBI Gene897344GenBank4982086
Pharmacology
KEGGtma:TM1521
Structure
PDB1O5KPDB3PB0PDB3PB2
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4-hydroxy-tetrahydrodipicolinate synthase, and which indications are they being tested in?

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