Aspartate/prephenate aminotransferase

BE0001465ProteinThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)aspC

Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate (PubMed:25070637, PubMed:8907187). It is acted on by 2 drugs in DrugBank.

Gene name
aspC
UniProtKB entry
Q56232Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
385 residues · 42,051 Da
Also known as
2.6.1.1 · Aspartate aminotransferase · AspAT · AspAT / PAT · Transaminase A

Resolves to

Protein
UniProtQ56232UniProt nameAAPAT_THET8
Gene
NCBI Gene3168657GenBank1255699
Pharmacology
KEGGttj:TTHA0046
Structure
PDB1B5OPDB1B5PPDB1BJW
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aspartate/prephenate aminotransferase, and which indications are they being tested in?

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