Lanosterol synthase

BE0001466ProteinHumansLSS

Key enzyme in the cholesterol biosynthesis pathway. It is acted on by 2 drugs in DrugBank.

Gene name
LSS
UniProtKB entry
P48449Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
732 residues · 83,308 Da
Also known as
2,3-epoxysqualene--lanosterol cyclase · 5.4.99.7 · hOSC · OSC · Oxidosqualene--lanosterol cyclase

Resolves to

Protein
UniProtP48449UniProt nameLSS_HUMAN
Gene
HGNCHGNC:6708NCBI Gene4047GenBank951314GeneCardsLSS
Pharmacology
IUPHAR/GtoPdb2434KEGGhsa:4047
Structure
PDB1W6JPDB1W6K
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Lanosterol synthase, and which indications are they being tested in?

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