Phosphoribosylglycinamide formyltransferase

BE0001476ProteinEscherichia coli (strain K12)purN

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. It is acted on by 4 drugs in DrugBank.

Gene name
purN
UniProtKB entry
P08179Swiss-Prot
Residues / weight
212 residues · 23,238 Da
Also known as
2.1.2.2 · 5'-phosphoribosylglycinamide transformylase · GAR transformylase · GART

Resolves to

Protein
UniProtP08179UniProt namePUR3_ECOLI
Gene
NCBI Gene946973GenBank147425
Pharmacology
KEGGecj:JW2485
Structure
PDB1C2TPDB1C3EPDB1CDD
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphoribosylglycinamide formyltransferase, and which indications are they being tested in?

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