2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Details
- Name
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
- Kind
- protein
- Synonyms
- 2.7.6.3
- 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
- 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
- HPPK
- PPPK
- Gene Name
- folK
- UniProtKB Entry
- P43777Swiss-Prot
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- NCBI Taxonomy ID
- 71421
- Amino acid sequence
>lcl|BSEQ0011051|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MITAYIALGSNLNTPVEQLHAALKAISQLSNTHLVTTSSFYKSKPLGPQDQPDYVNAVAK IETELSPLKLLDELQRIENEQGRVRLRRWGERTLDLDILLYGNEIIQNERLTIPHYDMHN REFVIVPLFEIASDLVLPNSQIITELVKQFADHKMIKLNP
- Number of residues
- 160
- Molecular Weight
- 18298.875
- Theoretical pI
- 6.0
- GO Classification
- Functions2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity / ATP binding / kinase activityProcessesfolic acid biosynthetic process / tetrahydrofolate biosynthetic process
- General Function
- Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
- Specific Function
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
- Pfam Domain Function
- HPPK (PF01288)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011052|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK) ATGATTACGGCATATATTGCTCTAGGTAGCAATTTAAACACACCAGTAGAACAATTACAT GCTGCGCTTAAAGCGATAAGTCAGTTATCAAACACTCATTTGGTAACAACGAGCTCTTTT TATAAAAGCAAACCGCTCGGCCCACAAGATCAACCCGATTATGTGAATGCCGTTGCAAAA ATTGAAACCGAACTTAGTCCGCTCAAGCTATTAGATGAATTACAGCGTATTGAAAACGAG CAAGGTCGAGTGCGTTTACGTCGCTGGGGCGAACGCACGTTAGATTTAGATATTTTGCTC TACGGCAATGAAATTATTCAAAACGAACGCTTAACAATTCCCCATTATGATATGCATAAC CGTGAGTTTGTCATTGTGCCGTTGTTTGAAATCGCATCGGATTTAGTTTTACCAAATAGT CAAATCATAACAGAGCTGGTCAAGCAATTTGCTGACCACAAAATGATAAAATTAAATCCC TAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P43777 UniProtKB Entry Name HPPK_HAEIN GenBank Protein ID 1573012 GenBank Gene ID L42023 PDB ID(s) 1CBK KEGG ID hin:HI0064 NCBI Gene ID 950962 - General References
- Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
- Hennig M, Dale GE, D'arcy A, Danel F, Fischer S, Gray CP, Jolidon S, Muller F, Page MG, Pattison P, Oefner C: The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae. J Mol Biol. 1999 Mar 26;287(2):211-9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 7,8-dihydro-7,7-dimethyl-6-hydroxypterin experimental unknown target Details