2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Details

Name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Kind
protein
Synonyms
  • 2.7.6.3
  • 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
  • 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
  • HPPK
  • PPPK
Gene Name
folK
UniProtKB Entry
P43777Swiss-Prot
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
NCBI Taxonomy ID
71421
Amino acid sequence
>lcl|BSEQ0011051|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MITAYIALGSNLNTPVEQLHAALKAISQLSNTHLVTTSSFYKSKPLGPQDQPDYVNAVAK
IETELSPLKLLDELQRIENEQGRVRLRRWGERTLDLDILLYGNEIIQNERLTIPHYDMHN
REFVIVPLFEIASDLVLPNSQIITELVKQFADHKMIKLNP
Number of residues
160
Molecular Weight
18298.875
Theoretical pI
6.0
GO Classification
Functions
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity / ATP binding / kinase activity
Processes
folic acid biosynthetic process / tetrahydrofolate biosynthetic process
General Function
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Specific Function
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011052|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
ATGATTACGGCATATATTGCTCTAGGTAGCAATTTAAACACACCAGTAGAACAATTACAT
GCTGCGCTTAAAGCGATAAGTCAGTTATCAAACACTCATTTGGTAACAACGAGCTCTTTT
TATAAAAGCAAACCGCTCGGCCCACAAGATCAACCCGATTATGTGAATGCCGTTGCAAAA
ATTGAAACCGAACTTAGTCCGCTCAAGCTATTAGATGAATTACAGCGTATTGAAAACGAG
CAAGGTCGAGTGCGTTTACGTCGCTGGGGCGAACGCACGTTAGATTTAGATATTTTGCTC
TACGGCAATGAAATTATTCAAAACGAACGCTTAACAATTCCCCATTATGATATGCATAAC
CGTGAGTTTGTCATTGTGCCGTTGTTTGAAATCGCATCGGATTTAGTTTTACCAAATAGT
CAAATCATAACAGAGCTGGTCAAGCAATTTGCTGACCACAAAATGATAAAATTAAATCCC
TAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP43777
UniProtKB Entry NameHPPK_HAEIN
GenBank Protein ID1573012
GenBank Gene IDL42023
PDB ID(s)1CBK
KEGG IDhin:HI0064
NCBI Gene ID950962
General References
  1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
  2. Hennig M, Dale GE, D'arcy A, Danel F, Fischer S, Gray CP, Jolidon S, Muller F, Page MG, Pattison P, Oefner C: The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae. J Mol Biol. 1999 Mar 26;287(2):211-9. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
7,8-dihydro-7,7-dimethyl-6-hydroxypterinexperimentalunknowntargetDetails