Chloramphenicol 3-O phosphotransferase

BE0001493ProteinStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

Inactivates chloramphenicol by catalyzing the transfer of the gamma-phosphate of ATP to the antibiotic's C-3' hydroxyl group. It is acted on by 4 drugs in DrugBank.

UniProtKB entry
Q56148Swiss-Prot
Residues / weight
178 residues · 18,816 Da
Also known as
2.7.1.- · CPT

Resolves to

Protein
UniProtQ56148UniProt nameCPT_STRVP
Gene
GenBank498888
Pharmacology
KEGGag:AAB36569
Structure
PDB1GRQPDB1GRRPDB1QHN
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Chloramphenicol 3-O phosphotransferase, how selective are they, and which programs against it are still in active trials?

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