Thymidylate synthase

BE0001501ProteinLactobacillus caseithyA

Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. It is acted on by 12 drugs in DrugBank.

Gene name
thyA
UniProtKB entry
P00469Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
316 residues · 36,579 Da
Also known as
2.1.1.45 · TS

Resolves to

Protein
UniProtP00469UniProt nameTYSY_LACCA
Gene
GenBank149601
Structure
PDB1BO7PDB1BO8PDB1BP0
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thymidylate synthase, and which indications are they being tested in?

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