Cathepsin F
Details
- Name
- Cathepsin F
- Kind
- protein
- Synonyms
- 3.4.22.41
- CATSF
- Gene Name
- CTSF
- UniProtKB Entry
- Q9UBX1Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0020541|Cathepsin F MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRA VLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLL RKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLP VKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLT EEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQ GHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPL RPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASS AVVD
- Number of residues
- 484
- Molecular Weight
- 53365.455
- Theoretical pI
- 8.33
- GO Classification
- Processesproteolysis involved in protein catabolic processComponentscollagen-containing extracellular matrix / endoplasmic reticulum / intracellular membrane-bounded organelle / plasma membrane
- General Function
- Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis
- Specific Function
- Cysteine-type endopeptidase activity
- Pfam Domain Function
- Signal Regions
- 1-19
- Transmembrane Regions
- Not Available
- Cellular Location
- Lysosome
- Gene sequence
>lcl|BSEQ0020542|Cathepsin F (CTSF) ATGGCGCCCTGGCTGCAGCTCCTGTCGCTGCTGGGGCTGCTCCCGGGCGCAGTGGCCGCC CCCGCCCAGCCCCGAGCCGCCAGCTTTCAGGCCTGGGGGCCGCCGTCCCCGGAGCTGCTG GCGCCCACCCGCTTCGCGCTGGAGATGTTCAACCGCGGCCGGGCTGCGGGGACGCGGGCC GTGCTGGGCCTTGTGCGCGGCCGCGTCCGCCGGGCGGGTCAGGGGTCGCTGTACTCCCTG GAGGCCACCCTGGAGGAGCCACCCTGCAACGACCCCATGGTGTGCCGGCTCCCCGTGTCC AAGAAAACCCTGCTCTGCAGCTTCCAAGTCCTGGATGAGCTCGGAAGACACGTGCTGCTG CGGAAGGACTGTGGCCCAGTGGACACCAAGGTTCCAGGTGCTGGGGAGCCCAAGTCAGCC TTCACTCAGGGCTCAGCCATGATTTCTTCTCTGTCCCAAAACCATCCAGACAACAGAAAC GAGACTTTCAGCTCAGTCATTTCCCTGTTGAATGAGGATCCCCTGTCCCAGGACTTGCCT GTGAAGATGGCTTCAATCTTCAAGAACTTTGTCATTACCTATAACCGGACATATGAGTCA AAGGAAGAAGCCCGGTGGCGCCTGTCCGTCTTTGTCAATAACATGGTGCGAGCACAGAAG ATCCAGGCCCTGGACCGTGGCACAGCTCAGTATGGAGTCACCAAGTTCAGTGATCTCACA GAGGAGGAGTTCCGCACTATCTACCTGAATACTCTCCTGAGGAAAGAGCCTGGCAACAAG ATGAAGCAAGCCAAGTCTGTGGGTGACCTCGCCCCACCTGAATGGGACTGGAGGAGTAAG GGGGCTGTCACAAAAGTCAAAGACCAGGGCATGTGTGGCTCCTGCTGGGCCTTCTCAGTC ACAGGCAATGTGGAGGGCCAGTGGTTTCTCAACCAGGGGACCCTGCTCTCCCTCTCTGAA CAGGAGCTCTTGGACTGTGACAAGATGGACAAGGCCTGCATGGGCGGCTTGCCCTCCAAT GCCTACTCGGCCATAAAGAATTTGGGAGGGCTGGAGACAGAGGATGACTACAGCTACCAG GGTCACATGCAGTCCTGCAACTTCTCAGCAGAGAAGGCCAAGGTCTACATCAATGACTCC GTGGAGCTGAGCCAGAACGAGCAGAAGCTGGCAGCCTGGCTGGCCAAGAGAGGCCCAATC TCCGTGGCCATCAATGCCTTTGGCATGCAGTTTTACCGCCACGGGATCTCCCGCCCTCTC CGGCCCCTCTGCAGCCCTTGGCTCATTGACCATGCGGTGTTGCTTGTGGGCTACGGCAAC CGCTCTGACGTTCCCTTTTGGGCCATCAAGAACAGCTGGGGCACTGACTGGGGTGAGAAG GGTTACTACTACTTGCATCGTGGGTCCGGGGCCTGTGGCGTGAACACCATGGCCAGCTCG GCGGTGGTGGACTGA
- Chromosome Location
- 11
- Locus
- 11q13.2
- External Identifiers
Resource Link UniProtKB ID Q9UBX1 UniProtKB Entry Name CATF_HUMAN GenBank Protein ID 4826528 GenBank Gene ID AJ007331 GeneCard ID CTSF GenAtlas ID CTSF HGNC ID HGNC:2531 PDB ID(s) 1M6D KEGG ID hsa:8722 IUPHAR/Guide To Pharmacology ID 2347 NCBI Gene ID 8722 - General References
- Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C: Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. J Biol Chem. 1999 May 14;274(20):13800-9. [Article]
- Nagler DK, Sulea T, Menard R: Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen. Biochem Biophys Res Commun. 1999 Apr 13;257(2):313-8. [Article]
- Wex T, Wex H, Bromme D: The human cathepsin F gene--a fusion product between an ancestral cathepsin and cystatin gene. Biol Chem. 1999 Dec;380(12):1439-42. [Article]
- Wex T, Levy B, Wex H, Bromme D: Human cathepsins F and W: A new subgroup of cathepsins. Biochem Biophys Res Commun. 1999 Jun 7;259(2):401-7. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D: Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. 1998 Nov 27;273(48):32000-8. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
- Somoza JR, Palmer JT, Ho JD: The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators. J Mol Biol. 2002 Sep 20;322(3):559-68. [Article]
- Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grotzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M: Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Apr 1;22(7):1417-23. doi: 10.1093/hmg/dds558. Epub 2013 Jan 7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-Amide experimental unknown target Details [1-(1-Methyl-4,5-Dioxo-Pent-2-Enylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester experimental unknown target Details HOMOPHENYLALANINYLMETHANE experimental unknown target Details WRR-99 experimental yes target inhibitor Details WRR-112 experimental yes target inhibitor Details [1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester experimental unknown target Details Benzyl N-[(2S)-5-(diaminomethylamino)-1-[[(2S)-4-fluoro-3-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamate experimental unknown target Details Benzoyl-tyrosine-alanine-fluoro-methyl ketone experimental unknown target Details