2,2-dialkylglycine decarboxylase
Details
- Name
- 2,2-dialkylglycine decarboxylase
- Kind
- protein
- Synonyms
- 4.1.1.64
- DGD
- Gene Name
- dgdA
- UniProtKB Entry
- P16932Swiss-Prot
- Organism
- Pseudomonas cepacia
- NCBI Taxonomy ID
- 292
- Amino acid sequence
>lcl|BSEQ0011063|2,2-dialkylglycine decarboxylase MSLNDDATFWRNARQHLVRYGGTFEPMIIERAKGSFVYDADGRAILDFTSGQMSAVLGHC HPEIVSVIGEYAGKLDHLFSGMLSRPVVDLATRLANITPPGLDRALLLSTGAESNEAAIR MAKLVTGKYEIVGFAQSWHGMTGAAASATYSAGRKGVGPAAVGSFAIPAPFTYRPRFERN GAYDYLAELDYAFDLIDRQSSGNLAAFIAEPILSSGGIIELPDGYMAALKRKCEARGMLL ILDEAQTGVGRTGTMFACQRDGVTPDILTLSKTLGAGLPLAAIVTSAAIEERAHELGYLF YTTHVSDPLPAAVGLRVLDVVQRDGLVARANVMGDRLRRGLLDLMERFDCIGDVRGRGLL LGVEIVKDRRTKEPADGLGAKITRECMNLGLSMNIVQLPGMGGVFRIAPPLTVSEDEIDL GLSLLGQAIERAL
- Number of residues
- 433
- Molecular Weight
- 46443.91
- Theoretical pI
- 5.95
- GO Classification
- Functions2,2-dialkylglycine decarboxylase (pyruvate) activity / pyridoxal phosphate binding / transaminase activity
- General Function
- The dialkylglycine decarboxylase is of interest because it normally catalyzes both decarboxylation and amino transfer. It may be more properly described as a decarboxylating aminotransferase rather than an aminotransferring decarboxylase.
- Specific Function
- 2,2-dialkylglycine decarboxylase (pyruvate) activity
- Pfam Domain Function
- Aminotran_3 (PF00202)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002989|1302 bp ATGTCCCTGAACGACGATGCAACCTTCTGGCGCAACGCCAGGCAGCACCTGGTCCGCTAC GGCGGCACGTTCGAGCCGATGATCATCGAGCGCGCGAAGGGCAGCTTCGTCTATGACGCC GACGGCCGCGCGATCCTCGATTTCACGTCGGGGCAGATGAGCGCGGTGCTCGGCCACTGC CATCCGGAGATCGTCTCCGTCATCGGCGAATACGCGGGCAAGCTCGATCACCTGTTCAGC GGAATGCTGTCGCGGCCCGTCGTCGACCTCGCGACGCGCCTCGCCAACATCACGCCGCCC GGGCTCGACCGCGCGCTGCTGCTCAGCACCGGCGCGGAATCGAACGAAGCGGCAATCCGG ATGGCGAAGCTCGTCACCGGCAAGTACGAGATCGTCGGCTTCGCGCAGTCGTGGCACGGG ATGACGGGCGCGGCCGCATCGGCCACGTACAGCGCGGGCCGCAAGGGTGTCGGCCCGGCC GCCGTCGGCTCGTTCGCGATTCCGGCGCCATTCACGTACCGGCCGCGCTTCGAGCGCAAC GGCGCGTACGACTATCTCGCCGAACTCGACTACGCGTTCGACCTGATCGACCGCCAGTCG AGCGGCAACCTCGCGGCATTCATCGCGGAGCCGATCCTCAGTTCGGGCGGGATCATCGAA CTGCCGGACGGCTACATGGCGGCGCTCAAGCGCAAGTGCGAGGCGCGCGGGATGCTGCTG ATCCTCGACGAGGCGCAGACGGGCGTCGGACGCACCGGCACGATGTTCGCGTGCCAGCGC GACGGCGTGACGCCCGACATCCTGACGCTGTCGAAAACGCTCGGCGCCGGGCTGCCGCTC GCGGCCATCGTGACGTCCGCGGCGATCGAGGAACGCGCGCACGAACTCGGCTACCTGTTC TATACGACGCACGTGTCCGATCCGCTGCCCGCGGCGGTCGGCCTGCGCGTGCTCGACGTG GTGCAGCGCGACGGGCTCGTCGCACGCGCGAACGTGATGGGCGACCGGCTCAGGCGCGGC CTGCTCGACCTGATGGAGCGGTTCGACTGCATCGGCGACGTGCGCGGGCGCGGGCTGCTG CTCGGCGTCGAGATCGTCAAGGATCGACGCACGAAAGAGCCGGCGGACGGCCTCGGCGCG AAGATCACGCGCGAGTGCATGAACCTCGGGCTCAGCATGAACATCGTGCAGTTGCCCGGC ATGGGCGGCGTGTTCCGGATCGCGCCGCCGCTGACGGTCAGCGAGGACGAGATCGATCTC GGCTTGTCGCTGCTCGGTCAGGCGATCGAACGCGCGCTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P16932 UniProtKB Entry Name DGDA_BURCE GenBank Protein ID 559963 GenBank Gene ID J05282 PDB ID(s) 1D7R, 1D7S, 1D7U, 1D7V, 1DGD, 1DGE, 1DKA, 1M0N, 1M0O, 1M0P, 1M0Q, 1Z3Z, 1ZC9, 1ZOB, 1ZOD, 2DKB - General References
- Keller JW, Baurick KB, Rutt GC, O'Malley MV, Sonafrank NL, Reynolds RA, Ebbesson LO, Vajdos FF: Pseudomonas cepacia 2,2-dialkylglycine decarboxylase. Sequence and expression in Escherichia coli of structural and repressor genes. J Biol Chem. 1990 Apr 5;265(10):5531-9. [Article]
- Toney MD, Hohenester E, Cowan SW, Jansonius JN: Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites. Science. 1993 Aug 6;261(5122):756-9. [Article]
- Hohenester E, Keller JW, Jansonius JN: An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase. Biochemistry. 1994 Nov 22;33(46):13561-70. [Article]
- Toney MD, Hohenester E, Keller JW, Jansonius JN: Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase. J Mol Biol. 1995 Jan 13;245(2):151-79. [Article]
- Malashkevich VN, Strop P, Keller JW, Jansonius JN, Toney MD: Crystal structures of dialkylglycine decarboxylase inhibitor complexes. J Mol Biol. 1999 Nov 19;294(1):193-200. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-N,O-cycloserylamide experimental unknown target Details N-Pyridoxyl-1-Amino-Cyclopropanecarboxylic Acid-5-Monophosphate experimental unknown target Details (5-Hydroxy-6-methyl-4-{[(E)-(3-oxo-1,2-oxazolidin-4-ylidene)amino]methyl}-3-pyridinyl)methyl dihydrogen phosphate experimental unknown target Details N-Pyridoxyl-2-Methylalanine-5-Phosphate experimental unknown target Details