2,2-dialkylglycine decarboxylase

Details

Name
2,2-dialkylglycine decarboxylase
Kind
protein
Synonyms
  • 4.1.1.64
  • DGD
Gene Name
dgdA
UniProtKB Entry
P16932Swiss-Prot
Organism
Pseudomonas cepacia
NCBI Taxonomy ID
292
Amino acid sequence
>lcl|BSEQ0011063|2,2-dialkylglycine decarboxylase
MSLNDDATFWRNARQHLVRYGGTFEPMIIERAKGSFVYDADGRAILDFTSGQMSAVLGHC
HPEIVSVIGEYAGKLDHLFSGMLSRPVVDLATRLANITPPGLDRALLLSTGAESNEAAIR
MAKLVTGKYEIVGFAQSWHGMTGAAASATYSAGRKGVGPAAVGSFAIPAPFTYRPRFERN
GAYDYLAELDYAFDLIDRQSSGNLAAFIAEPILSSGGIIELPDGYMAALKRKCEARGMLL
ILDEAQTGVGRTGTMFACQRDGVTPDILTLSKTLGAGLPLAAIVTSAAIEERAHELGYLF
YTTHVSDPLPAAVGLRVLDVVQRDGLVARANVMGDRLRRGLLDLMERFDCIGDVRGRGLL
LGVEIVKDRRTKEPADGLGAKITRECMNLGLSMNIVQLPGMGGVFRIAPPLTVSEDEIDL
GLSLLGQAIERAL
Number of residues
433
Molecular Weight
46443.91
Theoretical pI
5.95
GO Classification
Functions
2,2-dialkylglycine decarboxylase (pyruvate) activity / pyridoxal phosphate binding / transaminase activity
General Function
The dialkylglycine decarboxylase is of interest because it normally catalyzes both decarboxylation and amino transfer. It may be more properly described as a decarboxylating aminotransferase rather than an aminotransferring decarboxylase.
Specific Function
2,2-dialkylglycine decarboxylase (pyruvate) activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0002989|1302 bp
ATGTCCCTGAACGACGATGCAACCTTCTGGCGCAACGCCAGGCAGCACCTGGTCCGCTAC
GGCGGCACGTTCGAGCCGATGATCATCGAGCGCGCGAAGGGCAGCTTCGTCTATGACGCC
GACGGCCGCGCGATCCTCGATTTCACGTCGGGGCAGATGAGCGCGGTGCTCGGCCACTGC
CATCCGGAGATCGTCTCCGTCATCGGCGAATACGCGGGCAAGCTCGATCACCTGTTCAGC
GGAATGCTGTCGCGGCCCGTCGTCGACCTCGCGACGCGCCTCGCCAACATCACGCCGCCC
GGGCTCGACCGCGCGCTGCTGCTCAGCACCGGCGCGGAATCGAACGAAGCGGCAATCCGG
ATGGCGAAGCTCGTCACCGGCAAGTACGAGATCGTCGGCTTCGCGCAGTCGTGGCACGGG
ATGACGGGCGCGGCCGCATCGGCCACGTACAGCGCGGGCCGCAAGGGTGTCGGCCCGGCC
GCCGTCGGCTCGTTCGCGATTCCGGCGCCATTCACGTACCGGCCGCGCTTCGAGCGCAAC
GGCGCGTACGACTATCTCGCCGAACTCGACTACGCGTTCGACCTGATCGACCGCCAGTCG
AGCGGCAACCTCGCGGCATTCATCGCGGAGCCGATCCTCAGTTCGGGCGGGATCATCGAA
CTGCCGGACGGCTACATGGCGGCGCTCAAGCGCAAGTGCGAGGCGCGCGGGATGCTGCTG
ATCCTCGACGAGGCGCAGACGGGCGTCGGACGCACCGGCACGATGTTCGCGTGCCAGCGC
GACGGCGTGACGCCCGACATCCTGACGCTGTCGAAAACGCTCGGCGCCGGGCTGCCGCTC
GCGGCCATCGTGACGTCCGCGGCGATCGAGGAACGCGCGCACGAACTCGGCTACCTGTTC
TATACGACGCACGTGTCCGATCCGCTGCCCGCGGCGGTCGGCCTGCGCGTGCTCGACGTG
GTGCAGCGCGACGGGCTCGTCGCACGCGCGAACGTGATGGGCGACCGGCTCAGGCGCGGC
CTGCTCGACCTGATGGAGCGGTTCGACTGCATCGGCGACGTGCGCGGGCGCGGGCTGCTG
CTCGGCGTCGAGATCGTCAAGGATCGACGCACGAAAGAGCCGGCGGACGGCCTCGGCGCG
AAGATCACGCGCGAGTGCATGAACCTCGGGCTCAGCATGAACATCGTGCAGTTGCCCGGC
ATGGGCGGCGTGTTCCGGATCGCGCCGCCGCTGACGGTCAGCGAGGACGAGATCGATCTC
GGCTTGTCGCTGCTCGGTCAGGCGATCGAACGCGCGCTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP16932
UniProtKB Entry NameDGDA_BURCE
GenBank Protein ID559963
GenBank Gene IDJ05282
PDB ID(s)1D7R, 1D7S, 1D7U, 1D7V, 1DGD, 1DGE, 1DKA, 1M0N, 1M0O, 1M0P, 1M0Q, 1Z3Z, 1ZC9, 1ZOB, 1ZOD, 2DKB
General References
  1. Keller JW, Baurick KB, Rutt GC, O'Malley MV, Sonafrank NL, Reynolds RA, Ebbesson LO, Vajdos FF: Pseudomonas cepacia 2,2-dialkylglycine decarboxylase. Sequence and expression in Escherichia coli of structural and repressor genes. J Biol Chem. 1990 Apr 5;265(10):5531-9. [Article]
  2. Toney MD, Hohenester E, Cowan SW, Jansonius JN: Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites. Science. 1993 Aug 6;261(5122):756-9. [Article]
  3. Hohenester E, Keller JW, Jansonius JN: An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase. Biochemistry. 1994 Nov 22;33(46):13561-70. [Article]
  4. Toney MD, Hohenester E, Keller JW, Jansonius JN: Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase. J Mol Biol. 1995 Jan 13;245(2):151-79. [Article]
  5. Malashkevich VN, Strop P, Keller JW, Jansonius JN, Toney MD: Crystal structures of dialkylglycine decarboxylase inhibitor complexes. J Mol Biol. 1999 Nov 19;294(1):193-200. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
D-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-N,O-cycloserylamideexperimentalunknowntargetDetails
N-Pyridoxyl-1-Amino-Cyclopropanecarboxylic Acid-5-MonophosphateexperimentalunknowntargetDetails
(5-Hydroxy-6-methyl-4-{[(E)-(3-oxo-1,2-oxazolidin-4-ylidene)amino]methyl}-3-pyridinyl)methyl dihydrogen phosphateexperimentalunknowntargetDetails
N-Pyridoxyl-2-Methylalanine-5-PhosphateexperimentalunknowntargetDetails