Chorismate pyruvate-lyase

BE0001507ProteinEscherichia coli (strain K12)ubiC

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. It is acted on by 2 drugs in DrugBank.

Gene name
ubiC
UniProtKB entry
P26602Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
165 residues · 18,777 Da
Also known as
4.1.3.40 · CL

Resolves to

Protein
UniProtP26602UniProt nameUBIC_ECOLI
Gene
NCBI Gene948545GenBank43231
Pharmacology
KEGGecj:JW5713
Structure
PDB1FW9PDB1G1BPDB1G81
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Chorismate pyruvate-lyase, and which indications are they being tested in?

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