5'(3')-deoxyribonucleotidase, mitochondrial

BE0001515ProteinHumansNT5M

Dephosphorylates preferentially the 5'- and 2'(3')-phosphates of uracil and thymine (deoxy)ribonucleotide monophosphates (PubMed:10899995, PubMed:16004879). It is acted on by 2 drugs in DrugBank.

Gene name
NT5M
UniProtKB entry
Q9NPB1Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
228 residues · 25,862 Da
Also known as
3.1.3.- · 5',3'-nucleotidase, mitochondrial · Deoxy-5'-nucleotidase 2 · dNT-2 · DNT2

Resolves to

Protein
UniProtQ9NPB1UniProt nameNT5M_HUMAN
Gene
HGNCHGNC:15769NCBI Gene56953GenBank9408106GeneCardsNT5M
Pharmacology
KEGGhsa:56953
Structure
PDB1MH9PDB1Q91PDB1Q92
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 5'(3')-deoxyribonucleotidase, mitochondrial, and which indications are they being tested in?

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