Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

BE0001519ProteinEscherichia coli (strain K12)bioA

Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (PubMed:1092681, PubMed:1092682). It is acted on by 3 drugs in DrugBank.

Gene name
bioA
UniProtKB entry
P12995Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
429 residues · 47,335 Da
Also known as
2.6.1.62 · 7,8-diamino-pelargonic acid aminotransferase · 7,8-diaminononanoate synthase · DANS · DAPA aminotransferase

Resolves to

Protein
UniProtP12995UniProt nameBIOA_ECOLI
Gene
NCBI Gene945376GenBank457106
Pharmacology
KEGGecj:JW0757
Structure
PDB1DTYPDB1MGVPDB1MLY
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and which indications are they being tested in?

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