8-oxo-dGTP diphosphatase

BE0001520ProteinEscherichia coli (strain K12)mutT

Specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to the related monophosphates, thereby cleaning up the nucleotide pools and preventing misincorporation of 8-oxoGua into DNA and RNA (PubMed:1309939, PubMed:15850400, PubMed:9311918). It is acted on by 1 drug in DrugBank.

Gene name
mutT
UniProtKB entry
P08337Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
129 residues · 14,927 Da
Also known as
3.6.1.55 · 7,8-dihydro-8-oxoguanine-triphosphatase · 8-oxo-dGTPase · dGTP pyrophosphohydrolase · Mutator protein MutT

Resolves to

Protein
UniProtP08337UniProt nameMUTT_ECOLI
Gene
NCBI Gene944824GenBank42071
Pharmacology
KEGGecj:JW0097
Structure
PDB1MUTPDB1PPXPDB1PUN
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 8-oxo-dGTP diphosphatase, and which indications are they being tested in?

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