3-deoxy-manno-octulosonate cytidylyltransferase

BE0001522ProteinEscherichia colikpsU

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. It is acted on by 5 drugs in DrugBank.

Gene name
kpsU
UniProtKB entry
P42216Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
246 residues · 27,159 Da
Also known as
2.7.7.38 · CKS · CMP-2-keto-3-deoxyoctulosonic acid synthase · CMP-KDO synthase

Resolves to

Protein
UniProtP42216UniProt nameKPSU5_ECOLX
Gene
GenBank397407
Structure
PDB1GQ9PDB1GQCPDB1H6J
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-deoxy-manno-octulosonate cytidylyltransferase, and which indications are they being tested in?

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