Septum formation protein Maf

Details

Name
Septum formation protein Maf
Kind
protein
Synonyms
Not Available
Gene Name
maf
UniProtKB Entry
Q02169Swiss-Prot
Organism
Bacillus subtilis (strain 168)
NCBI Taxonomy ID
224308
Amino acid sequence
>lcl|BSEQ0016463|Septum formation protein Maf
MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEENVQWLAKQKAKAVADL
HPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHSVITAVSIQAENHSETFYD
KTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFVKKIDGDYYSVMGLPISKTMR
ALRHFDIRA
Number of residues
189
Molecular Weight
21295.18
Theoretical pI
6.03
GO Classification
Components
cytoplasm
General Function
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-CTP (m(5)CTP) and 5-methyl-UTP (m(5)UTP) (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219).
Specific Function
dTTP diphosphatase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0016464|Septum formation protein Maf (maf)
ATGACAAAACCGCTAATACTTGCATCACAATCTCCGCGCAGGAAAGAACTCCTCGATCTT
CTCCAGCTGCCCTACTCCATTATTGTCAGTGAAGTAGAAGAAAAATTAAATCGAAACTTT
TCACCAGAAGAAAACGTCCAATGGTTGGCAAAACAAAAAGCTAAGGCTGTAGCTGATCTC
CACCCGCATGCAATCGTTATCGGTGCTGATACAATGGTATGCCTTGACGGCGAATGTCTT
GGCAAACCGCAGGATCAAGAAGAAGCTGCTTCTATGCTGCGGAGGCTTTCAGGCCGAAGT
CACTCAGTAATAACCGCGGTCAGCATTCAAGCTGAAAATCACAGCGAGACTTTTTATGAT
AAGACAGAAGTTGCGTTTTGGTCCCTCAGTGAAGAAGAGATTTGGACATATATTGAAACA
AAAGAGCCGATGGATAAAGCAGGTGCATACGGCATCCAAGGAAGAGGCGCGCTTTTTGTA
AAGAAAATAGACGGAGATTATTATTCAGTCATGGGCCTTCCTATATCAAAAACAATGAGA
GCTCTTCGCCATTTTGATATAAGGGCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ02169
UniProtKB Entry NameMAF_BACSU
GenBank Protein ID143161
GenBank Gene IDL08793
PDB ID(s)1EX2, 1EXC, 4HEB
KEGG IDbsu:BSU28050
NCBI Gene ID936605
General References
  1. Butler YX, Abhayawardhane Y, Stewart GC: Amplification of the Bacillus subtilis maf gene results in arrested septum formation. J Bacteriol. 1993 May;175(10):3139-45. [Article]
  2. Levin PA, Margolis PS, Setlow P, Losick R, Sun D: Identification of Bacillus subtilis genes for septum placement and shape determination. J Bacteriol. 1992 Nov;174(21):6717-28. [Article]
  3. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  4. Margolis PS, Driks A, Losick R: Sporulation gene spoIIB from Bacillus subtilis. J Bacteriol. 1993 Jan;175(2):528-40. [Article]
  5. Minasov G, Teplova M, Stewart GC, Koonin EV, Anderson WF, Egli M: Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6328-33. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Deoxyuridine-5'-TriphosphateexperimentalunknowntargetDetails