Septum formation protein Maf
Details
- Name
- Septum formation protein Maf
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- maf
- UniProtKB Entry
- Q02169Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0016463|Septum formation protein Maf MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEENVQWLAKQKAKAVADL HPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHSVITAVSIQAENHSETFYD KTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFVKKIDGDYYSVMGLPISKTMR ALRHFDIRA
- Number of residues
- 189
- Molecular Weight
- 21295.18
- Theoretical pI
- 6.03
- GO Classification
- Componentscytoplasm
- General Function
- Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-CTP (m(5)CTP) and 5-methyl-UTP (m(5)UTP) (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219).
- Specific Function
- dTTP diphosphatase activity
- Pfam Domain Function
- Maf (PF02545)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016464|Septum formation protein Maf (maf) ATGACAAAACCGCTAATACTTGCATCACAATCTCCGCGCAGGAAAGAACTCCTCGATCTT CTCCAGCTGCCCTACTCCATTATTGTCAGTGAAGTAGAAGAAAAATTAAATCGAAACTTT TCACCAGAAGAAAACGTCCAATGGTTGGCAAAACAAAAAGCTAAGGCTGTAGCTGATCTC CACCCGCATGCAATCGTTATCGGTGCTGATACAATGGTATGCCTTGACGGCGAATGTCTT GGCAAACCGCAGGATCAAGAAGAAGCTGCTTCTATGCTGCGGAGGCTTTCAGGCCGAAGT CACTCAGTAATAACCGCGGTCAGCATTCAAGCTGAAAATCACAGCGAGACTTTTTATGAT AAGACAGAAGTTGCGTTTTGGTCCCTCAGTGAAGAAGAGATTTGGACATATATTGAAACA AAAGAGCCGATGGATAAAGCAGGTGCATACGGCATCCAAGGAAGAGGCGCGCTTTTTGTA AAGAAAATAGACGGAGATTATTATTCAGTCATGGGCCTTCCTATATCAAAAACAATGAGA GCTCTTCGCCATTTTGATATAAGGGCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q02169 UniProtKB Entry Name MAF_BACSU GenBank Protein ID 143161 GenBank Gene ID L08793 PDB ID(s) 1EX2, 1EXC, 4HEB KEGG ID bsu:BSU28050 NCBI Gene ID 936605 - General References
- Butler YX, Abhayawardhane Y, Stewart GC: Amplification of the Bacillus subtilis maf gene results in arrested septum formation. J Bacteriol. 1993 May;175(10):3139-45. [Article]
- Levin PA, Margolis PS, Setlow P, Losick R, Sun D: Identification of Bacillus subtilis genes for septum placement and shape determination. J Bacteriol. 1992 Nov;174(21):6717-28. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Margolis PS, Driks A, Losick R: Sporulation gene spoIIB from Bacillus subtilis. J Bacteriol. 1993 Jan;175(2):528-40. [Article]
- Minasov G, Teplova M, Stewart GC, Koonin EV, Anderson WF, Egli M: Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6328-33. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Deoxyuridine-5'-Triphosphate experimental unknown target Details