Elastase

BE0001528ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)lasB

Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase (PubMed:11533066). It is acted on by 2 drugs in DrugBank.

Gene name
lasB
UniProtKB entry
P14756Swiss-Prot
Cellular location
Secreted
Residues / weight
498 residues · 53,687 Da
Also known as
3.4.24.26 · Neutral metalloproteinase · PAE · Pseudolysin

Resolves to

Protein
UniProtP14756UniProt nameELAS_PSEAE
Gene
NCBI Gene880368GenBank151210
Pharmacology
KEGGpae:PA3724
Structure
PDB1EZMPDB1U4GPDB3DBK
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Elastase, and which indications are they being tested in?

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