Methionine--tRNA ligase

BE0001537ProteinEscherichia coli (strain K12)metG

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. It is acted on by 5 drugs in DrugBank.

Gene name
metG
UniProtKB entry
P00959Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
677 residues · 76,254 Da
Also known as
6.1.1.10 · Methionyl transfer RNA synthetase · Methionyl-tRNA synthetase · MetRS · MTS

Resolves to

Protein
UniProtP00959UniProt nameSYM_ECOLI
Gene
NCBI Gene946643GenBank146829
Pharmacology
KEGGecj:JW2101
Structure
PDB1F4LPDB1MEAPDB1MED
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Methionine--tRNA ligase, and which indications are they being tested in?

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