Pyridoxine 5'-phosphate synthase

BE0001540ProteinEscherichia coli (strain K12)pdxJ

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. It is acted on by 3 drugs in DrugBank.

Gene name
pdxJ
UniProtKB entry
P0A794Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
243 residues · 26,384 Da
Also known as
2.6.99.2 · PNP synthase

Resolves to

Protein
UniProtP0A794UniProt namePDXJ_ECOLI
Gene
NCBI Gene947039GenBank147555
Pharmacology
KEGGecj:JW2548
Structure
PDB1HO1PDB1HO4PDB1IXN
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Pyridoxine 5'-phosphate synthase, and which indications are they being tested in?

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