Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

BE0001541ProteinHumansHS3ST3A1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:10608887, PubMed:15304505, PubMed:9988768). It is acted on by 4 drugs in DrugBank.

Gene name
HS3ST3A1
UniProtKB entry
Q9Y663Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
406 residues · 44,899 Da
Also known as
2.8.2.30 · 3-OST-3A · 3OST3A1 · h3-OST-3A · Heparan sulfate 3-O-sulfotransferase 3A1

Resolves to

Protein
UniProtQ9Y663UniProt nameHS3SA_HUMAN
Gene
HGNCHGNC:5196NCBI Gene9955GenBank4835723GeneCardsHS3ST3A1
Pharmacology
KEGGhsa:9955
Structure
PDB1T8TPDB1T8UPDB6XKG
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Heparan sulfate glucosamine 3-O-sulfotransferase 3A1, and which indications are they being tested in?

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