Formate-dependent phosphoribosylglycinamide formyltransferase

BE0001547ProteinEscherichia coli (strain K12)purT

Involved in the de novo purine biosynthesis (PubMed:8117714, PubMed:8501063, PubMed:9184151). It is acted on by 5 drugs in DrugBank.

Gene name
purT
UniProtKB entry
P33221Swiss-Prot
Residues / weight
392 residues · 42,433 Da
Also known as
2.1.2.- · 5'-phosphoribosylglycinamide transformylase 2 · 6.3.1.21 · Formate-dependent GAR transformylase · GAR transformylase 2

Resolves to

Protein
UniProtP33221UniProt namePURT_ECOLI
Gene
NCBI Gene946368GenBank304887
Pharmacology
KEGGecj:JW1838
Structure
PDB1EYZPDB1EZ1PDB1KJ8
Drugs

What you can answer from here — as of May 03, 2025

5DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Formate-dependent phosphoribosylglycinamide formyltransferase, and which indications are they being tested in?

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