Squalene--hopene cyclase

BE0001553ProteinAlicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / 104-1A)shc

Catalyzes the cyclization of squalene into hopene. It is acted on by 11 drugs in DrugBank.

Gene name
shc
UniProtKB entry
P33247Swiss-Prot
Cellular location
Cell membrane
Residues / weight
631 residues · 71,570 Da
Also known as
4.2.1.129 · 5.4.99.17 · SHC · Squalene--hopanol cyclase

Resolves to

Protein
UniProtP33247UniProt nameSQHC_ALIAD
Gene
GenBank987617
Pharmacology
KEGGaac:Aaci_2443
Structure
PDB1GSZPDB1H35PDB1H36
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Squalene--hopene cyclase, and which indications are they being tested in?

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