Beta-lactamase IMP-1
Details
- Name
- Beta-lactamase IMP-1
- Kind
- protein
- Synonyms
- 3.5.2.6
- Beta-lactamase type II
- BLAIMP
- Penicillinase
- Gene Name
- Not Available
- UniProtKB Entry
- P52699Swiss-Prot
- Organism
- Serratia marcescens
- NCBI Taxonomy ID
- 615
- Amino acid sequence
>lcl|BSEQ0021977|Beta-lactamase IMP-1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK PSKPSN
- Number of residues
- 246
- Molecular Weight
- 27119.985
- Theoretical pI
- 8.94
- GO Classification
- Functionsbeta-lactamase activity / zinc ion bindingProcessesantibiotic catabolic process / response to antibiotic
- General Function
- Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
- Specific Function
- beta-lactamase activity
- Pfam Domain Function
- Lactamase_B (PF00753)
- Signal Regions
- 1-18
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003094|741 bp ATGAGCAAGTTATCTGTATTCTTTATATTTTTGTTTTGCAGCATTGCTACCGCAGCAGAG TCTTTGCCAGATTTAAAAATTGAAAAGCTTGATGAAGGCGTTTATGTTCATACTTCGTTT GAAGAAGTTAACGGGTGGGGCGTTGTTCCTAAACATGGTTTGGTGGTTCTTGTAAATGCT GAGGCTTACCTAATTGACACTCCATTTACGGCTAAAGATACTGAAAAGTTAGTCACTTGG TTTGTGGAGCGTGGCTATAAAATAAAAGGCAGCATTTCCTCTCATTTTCATAGCGACAGC ACGGGCGGAATAGAGTGGCTTAATTCTCGATCTATCCCCACGTATGCATCTGAATTAACA AATGAACTGCTTAAAAAAGACGGTAAGGTTCAAGCCACAAATTCATTTAGCGGAGTTAAC TATTGGCTAGTTAAAAATAAAATTGAAGTTTTTTATCCAGGCCCGGGACACACTCCAGAT AACGTAGTGGTTTGGTTGCCTGAAAGGAAAATATTATTCGGTGGTTGTTTTATTAAACCG TACGGTTTAGGCAATTTGGGTGACGCAAATATAGAAGCTTGGCCAAAGTCCGCCAAATTA TTAAAGTCCAAATATGGTAAGGCAAAACTGGTTGTTCCAAGTCACAGTGAAGTTGGAGAC GCATCACTCTTGAAACTTACATTAGAGCAGGCGGTTAAAGGGTTAAACGAAAGTAAAAAA CCATCAAAACCAAGCAACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P52699 UniProtKB Entry Name BLAB_SERMA GenBank Protein ID 560552 GenBank Gene ID S71932 PDB ID(s) 1DD6, 1VGN, 1WUO, 1WUP, 2DOO, 4C1F, 4C1G KEGG ID ag:AAB30289 - General References
- Osano E, Arakawa Y, Wacharotayankun R, Ohta M, Horii T, Ito H, Yoshimura F, Kato N: Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Antimicrob Agents Chemother. 1994 Jan;38(1):71-8. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2,3-Bis-Benzo[1,3]Dioxol-5-Ylmethyl-Succinic Acid experimental unknown target Details 2-Benzo[1,3]Dioxol-5-Ylmethyl-3-Benzyl-Succinic Acid experimental unknown target Details Mercaptocarboxylate Inhibitor experimental unknown target Details 2-(3-OXO-PROPYLSULFANYLCARBONYL)-ETHANETHIOLATE experimental unknown target Details N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE experimental unknown target Details