Metallo-beta-lactamase IMP-1

BE0001559ProteinSerratia marcescens

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. It is acted on by 5 drugs in DrugBank.

UniProtKB entry
P52699Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
246 residues · 27,120 Da
Also known as
3.1.26.- · 3.5.2.6 · B2 metallo-beta-lactamase · Beta-lactamase IMP-1 · Beta-lactamase type II

Resolves to

Protein
UniProtP52699UniProt nameBLBI1_SERMA
Gene
GenBank560552
Pharmacology
KEGGag:AAB30289
Structure
PDB1DD6PDB1VGNPDB1WUO
Drugs

What you can answer from here — as of May 03, 2025

5DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Metallo-beta-lactamase IMP-1, and which indications are they being tested in?

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