Thiazole tautomerase

BE0001562ProteinBacillus subtilis (strain 168)tenI

Catalyzes the irreversible aromatization of 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate (cThz-P) to 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate (cThz-P), a step in the biosynthesis of the thiazole phosphate moiety of thiamine. It is acted on by 1 drug in DrugBank.

Gene name
tenI
UniProtKB entry
P25053Swiss-Prot
Residues / weight
205 residues · 22,928 Da
Also known as
5.3.99.10

Resolves to

Protein
UniProtP25053UniProt nameTENI_BACSU
Gene
NCBI Gene936411
Pharmacology
KEGGbsu:BSU11660
Structure
PDB1YADPDB3QH2
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thiazole tautomerase, and which indications are they being tested in?

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