Thiazole tautomerase
Details
- Name
- Thiazole tautomerase
- Kind
- protein
- Synonyms
- 5.3.99.10
- Gene Name
- tenI
- UniProtKB Entry
- P25053Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0016476|Thiazole tautomerase MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILKLLDLIFEGGIDKRKLV MNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVHSLEEAVQAEKEDADYVLF GHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPDRLRDVKQAGADGIAVMSGIF SSAEPLEAARRYSRKLKEMRYEKAL
- Number of residues
- 205
- Molecular Weight
- 22928.24
- Theoretical pI
- 8.49
- GO Classification
- Functionsisomerase activity / thiamine-phosphate diphosphorylase activityProcessesthiamine biosynthetic process / thiamine diphosphate biosynthetic process
- General Function
- Catalyzes the irreversible aromatization of 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate (cThz*-P) to 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate (cThz-P), a step in the biosynthesis of the thiazole phosphate moiety of thiamine. Cannot use cThz* as substrate, indicating that the phosphate group is essential. Has no thiamine phosphate synthase activity, despite a high sequence similarity with ThiE.
- Specific Function
- isomerase activity
- Pfam Domain Function
- TMP-TENI (PF02581)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016477|Thiazole tautomerase (tenI) GTGGAGCTTCACGCCATAACGGATGACAGCAAGCCGGTAGAAGAGCTAGCGAGAATCATC ATTACGATTCAGAATGAAGTTGATTTTATTCACATTCGGGAACGCTCAAAATCGGCGGCG GATATTTTGAAACTGCTCGATCTTATTTTTGAAGGCGGTATAGATAAACGAAAATTGGTG ATGAACGGGCGCGTGGATATTGCACTTTTCTCTACTATTCACCGCGTGCAGCTGCCAAGC GGCAGCTTTTCACCGAAGCAGATCAGAGCCAGATTTCCACACCTTCATATCGGGAGGTCG GTGCATTCACTGGAGGAAGCGGTTCAAGCAGAAAAGGAAGACGCGGACTACGTGCTGTTC GGCCATGTGTTTGAAACGGATTGCAAAAAGGGTCTTGAAGGCAGAGGAGTATCTTTGCTG TCAGATATCAAACAGCGGATTTCCATCCCGGTTATAGCCATCGGGGGGATGACGCCGGAC AGGTTAAGAGACGTAAAACAAGCAGGGGCAGACGGCATTGCTGTTATGTCAGGAATTTTC TCTTCCGCTGAACCTTTGGAAGCAGCCAGACGATATTCCCGCAAGCTAAAGGAGATGCGC TATGAAAAGGCATTATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P25053 UniProtKB Entry Name TENI_BACSU GenBank Gene ID M73546 PDB ID(s) 1YAD, 3QH2 KEGG ID bsu:BSU11660 NCBI Gene ID 936411 - General References
- Pang AS, Nathoo S, Wong SL: Cloning and characterization of a pair of novel genes that regulate production of extracellular enzymes in Bacillus subtilis. J Bacteriol. 1991 Jan;173(1):46-54. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Lee JM, Zhang S, Saha S, Santa Anna S, Jiang C, Perkins J: RNA expression analysis using an antisense Bacillus subtilis genome array. J Bacteriol. 2001 Dec;183(24):7371-80. [Article]
- Toms AV, Haas AL, Park JH, Begley TP, Ealick SE: Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 2005 Feb 22;44(7):2319-29. [Article]
- Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP: A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase. J Am Chem Soc. 2011 Jun 22;133(24):9311-9. doi: 10.1021/ja1110514. Epub 2011 May 26. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Tris-Hydroxymethyl-Methyl-Ammonium experimental unknown target Details