Beta-lactamase TEM

BE0001568ProteinSalmonella typhibla

TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. It is acted on by 7 drugs in DrugBank.

Gene name
bla
UniProtKB entry
P62594Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
286 residues · 31,515 Da
Also known as
3.5.2.6 · Penicillinase

Resolves to

Protein
UniProtP62594UniProt nameBLAT_SALTI
Gene
NCBI Gene1251335GenBank16505919
Pharmacology
KEGGsty:HCM1.216
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-lactamase TEM, how selective are they, and which programs against it are still in active trials?

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