4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Details

Name
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Kind
protein
Synonyms
  • 2.7.1.148
  • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
  • CMK
Gene Name
ispE
UniProtKB Entry
Q83LD8Swiss-Prot
Organism
Shigella flexneri
NCBI Taxonomy ID
623
Amino acid sequence
>lcl|BSEQ0011115|4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
MRTQWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTISIELRDDGDIRLLTPVEGV
EHEDNLIVRAARLLMKTAADSGRLPTGSGANISIDKRLPMGGGLGGGSSNAATVLVALNH
LWQCGLSMDELAEMGLTLGADVPVFVRGHAAFAEGVGEILTPVDPPEKWYLVAHPGVSIP
TPVIFKDPELPRNTPKRSIETLLKCEFSNDCEVIARKRFREVDAVLSWLLEYAPSRLTGT
GACVFAEFDTESEARQVLEQAPEWLNGFVAKGVNLSPLHRAML
Number of residues
283
Molecular Weight
30953.11
Theoretical pI
4.91
GO Classification
Functions
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity / ATP binding
Processes
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway / terpenoid biosynthetic process
General Function
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Specific Function
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011116|4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE)
ATGCGGACACAGTGGCCCTCTCCGGCAAAACTTAATCTGTTTTTATACATTACCGGTCAG
CGTGCGGATGGTTACCACACGCTGCAAACGCTGTTTCAGTTTCTTGATTACGGCGACACC
ATCAGCATTGAGCTTCGTGACGATGGGGATATTCGTCTGTTAACGCCCGTTGAAGGCGTG
GAACATGAAGATAACCTGATCGTTCGCGCAGCGCGGTTGTTGATGAAAACTGCGGCAGAC
AGCGGGCGTCTTCCGACGGGAAGCGGTGCGAATATCAGCATTGACAAGCGTTTGCCGATG
GGCGGCGGTCTCGGCGGTGGTTCATCCAATGCCGCGACGGTCCTGGTGGCATTAAATCAT
CTCTGGCAATGCGGGCTAAGCATGGATGAGCTGGCGGAAATGGGGCTGACGCTGGGCGCA
GATGTTCCTGTCTTTGTTCGGGGGCATGCCGCGTTTGCCGAAGGCGTTGGTGAAATACTA
ACGCCGGTGGATCCGCCAGAGAAGTGGTATCTGGTGGCGCACCCTGGTGTAAGTATTCCG
ACTCCGGTGATTTTTAAAGATCCTGAACTCCCGCGCAATACGCCAAAAAGGTCAATAGAA
ACGTTGCTAAAATGTGAATTCAGCAATGATTGCGAGGTTATCGCAAGAAAACGTTTTCGC
GAGGTTGATGCGGTGCTTTCCTGGCTGTTAGAATACGCCCCGTCACGCCTGACTGGGACA
GGGGCCTGTGTCTTTGCTGAATTTGATACAGAGTCTGAAGCCCGCCAGGTGCTAGAGCAA
GCCCCGGAATGGCTCAATGGCTTTGTGGCGAAAGGCGTTAATCTTTCCCCATTGCACAGA
GCCATGCTTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ83LD8
UniProtKB Entry NameISPE_SHIFL
GenBank Protein ID24051512
GenBank Gene IDAE005674
KEGG IDsfl:SF1211
NCBI Gene ID1024154
General References
  1. Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
  2. Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritolexperimentalunknowntargetDetails
Phosphoaminophosphonic Acid-Adenylate EsterexperimentalunknowntargetDetails