1-deoxy-D-xylulose 5-phosphate reductoisomerase

BE0001575ProteinEscherichia coli (strain K12)dxr

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). It is acted on by 3 drugs in DrugBank.

Gene name
dxr
UniProtKB entry
P45568Swiss-Prot
Residues / weight
398 residues · 43,388 Da
Also known as
1-deoxyxylulose-5-phosphate reductoisomerase · 1.1.1.267 · 2-C-methyl-D-erythritol 4-phosphate synthase · DXP reductoisomerase · ispC

Resolves to

Protein
UniProtP45568UniProt nameDXR_ECOLI
Gene
NCBI Gene945019GenBank3434984
Pharmacology
KEGGecj:JW0168
Structure
PDB1JVSPDB1K5HPDB1ONN
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 1-deoxy-D-xylulose 5-phosphate reductoisomerase, and which indications are they being tested in?

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