Purine nucleoside phosphorylase

BE0001576ProteinMycobacterium tuberculosispunA

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. It is acted on by 3 drugs in DrugBank.

Gene name
punA
UniProtKB entry
P9WP01Swiss-Prot
Residues / weight
268 residues · 27,571 Da
Also known as
2.4.2.1 · deoD · Inosine phosphorylase · Inosine-guanosine phosphorylase · PNP

Resolves to

Protein
UniProtP9WP01UniProt namePUNA_MYCTU
Gene
NCBI Gene887542
Pharmacology
KEGGmtu:Rv3307
Structure
PDB1G2OPDB1I80PDB1N3I
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Purine nucleoside phosphorylase, and which indications are they being tested in?

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