4-hydroxythreonine-4-phosphate dehydrogenase

BE0001581ProteinEscherichia coli (strain K12)pdxA

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). It is acted on by 1 drug in DrugBank.

Gene name
pdxA
UniProtKB entry
P19624Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
329 residues · 35,113 Da
Also known as
1.1.1.262 · 4-(phosphohydroxy)-L-threonine dehydrogenase

Resolves to

Protein
UniProtP19624UniProt namePDXA_ECOLI
Gene
NCBI Gene944919GenBank147119
Pharmacology
KEGGecj:JW0051
Structure
PDB1PS6PDB1PS7PDB1PTM
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4-hydroxythreonine-4-phosphate dehydrogenase, and which indications are they being tested in?

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