Gamma-aminobutyraldehyde dehydrogenase

BE0001582ProteinEscherichia coli (strain K12)patD

Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA) (PubMed:16023116, PubMed:3510672). It is acted on by 1 drug in DrugBank.

Gene name
patD
UniProtKB entry
P77674Swiss-Prot
Residues / weight
474 residues · 50,830 Da
Also known as
1-pyrroline dehydrogenase · 1.2.1.19 · 4-aminobutanal dehydrogenase · 5-aminopentanal dehydrogenase · ABALDH

Resolves to

Protein
UniProtP77674UniProt nameABDH_ECOLI
Gene
NCBI Gene945876GenBank1787715
Pharmacology
KEGGecj:JW1439
Structure
PDB1WNBPDB1WND
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
7+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Gamma-aminobutyraldehyde dehydrogenase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In