Trypsin-3

BE0001583ProteinHumansPRSS3

Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. It is acted on by 8 drugs in DrugBank.

Gene name
PRSS3
UniProtKB entry
P35030Swiss-Prot
Cellular location
Secreted
Residues / weight
304 residues · 32,529 Da
Also known as
3.4.21.4 · Brain trypsinogen · Mesotrypsin · Mesotrypsinogen · PRSS4

Resolves to

Protein
UniProtP35030UniProt nameTRY3_HUMAN
Gene
HGNCHGNC:9486NCBI Gene5646GenBank6066378GeneCardsPRSS3
Pharmacology
IUPHAR/GtoPdb2399KEGGhsa:5646
Structure
PDB1H4WPDB2R9PPDB3L33
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Trypsin-3, and which indications are they being tested in?

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