ATP-dependent DNA helicase RecQ

BE0001592ProteinEscherichia coli (strain K12)recQ

An ATP-dependent DNA helicase which unwinds DNA in a 3'-5' direction (PubMed:12771204, PubMed:16084389, PubMed:2164680, PubMed:9553043). It is acted on by 1 drug in DrugBank.

Gene name
recQ
UniProtKB entry
P15043Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
609 residues · 68,363 Da
Also known as
3.6.4.12 · 5.6.2.4 · DNA 3'-5' helicase RecQ

Resolves to

Protein
UniProtP15043UniProt nameRECQ_ECOLI
Gene
NCBI Gene948318GenBank147559
Pharmacology
KEGGecj:JW5855
Structure
PDB1OYWPDB1OYYPDB1WUD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on ATP-dependent DNA helicase RecQ, and which indications are they being tested in?

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